Kai Kessenbrock

This study shows that restoring IL-15 signaling enhances group 1 ILCs' anti-tumor activity in brain metastasis, reducing tumor burden through improved cytotoxicity and tissue residency.

This study identifies two cell-of-origin-driven subtypes of BRCA1-associated TNBC, showing that tumor subtype depends on the cell type initiating the cancer.

This study identifies a conserved CD74+ macrophage niche driven by MIF-CD74 signaling that supports multi-organ metastasis in breast cancer and shows its therapeutic targeting reduces metastatic burden.

This study identifies PHLDA2 as a driver of breast cancer metastasis by reactivating a placental vascular remodeling program through hypomethylation and SPARC-mediated effects.

This paper constructs a comprehensive spatially resolved single-cell genomic atlas of the adult human breast, identifying 11 major cell types and revealing diverse immune and epithelial cell populations.

The paper uses single-cell transcriptomics to define basal cell states in skin homeostasis and wound healing, identifying distinct transcriptional states and their dynamics.

The paper introduces LandSCENT, a computational method to identify bipotent-like cells in mammary epithelium, which are associated with breast cancer risk.