Author

Isabelle M. A. Lombaert

University of MichiganORCID 0000-0002-7547-6375Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Bioengineering· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Organism:mouse· 2 Assay:proteomics· 2 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

Danielle WuiD· 2 shared Iva VeseláiD· 2 shared Mary C. Farach‐CarsoniD· 2 shared Thaise C. GeremiasiD· 2 shared Akash R. Gandhi· 1 shared Akshayapriya Saravanan· 1 shared ANDREW M. FARACHiD· 1 shared Bo SuniD· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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2 shared papersBioengineering

Danielle WuORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Assessing Bioactivity and Biointegration of Engineered Salivary Tissue Constructs in a Preclinical Unilateral Fractionated Irradiated Rat Model

Kerry Pernick, Juliana Amorim dos Santos, Caio César da Silva Barros, Iva Veselá, Meng-Jia Lian, Samuel Nahass, Thaise C. Geremias, Warren C. Swegal, ANDREW M. FARACH, Daniel A. Harrington, Danielle Wu, Mary C. Farach‐Carson, Isabelle M. A. Lombaert

This study evaluates the bioactivity and biointegration of engineered salivary tissue constructs in a rat model of radiation injury.

Acta Biomaterialia · Sep 1, 2026Peer-reviewedBioengineering

Trpv1+ sensory innervation of the salivary gland drives pain and supports saliva secretion

Deanna N. Cannizzaro, Juliana Amorim, Romy E. Wilson, Kayla M. Moehn, Akshayapriya Saravanan, Iva Veselá, Akash R. Gandhi, Isabelle M. A. Lombaert, Joshua J. Emrick

This study identifies Trpv1+ sensory neurons as critical for salivary gland structure and saliva secretion, showing their role in pain and function.

bioRxiv · Aug 12, 2026 · PreprintPhysiology

Optimizing Primary Human Salivary Stem/Progenitor Cells for Tissue Engineering Applications

Thaise C. Geremias, Fábio Henrique Brasil da Costa, Nadia G. Mohyuddin, Isabelle M. A. Lombaert, Mary C. Farach‐Carson, Danielle Wu

This paper establishes a xeno-free, serum-free protocol for isolating and expanding human salivary stem/progenitor cells suitable for regenerative therapy.

bioRxiv · May 13, 2026 · PreprintCell Biology

Rescue of non-healing, degenerative salivary glands by cholinergic-calcium signaling

Jianlong Li, Bo Sun, Li Xuan Tan, Nathan Griffin, Seyyed Vahid Niknezhad, Chieh Yu, Lionel Berthoin, Noel Cruz‐Pacheco, Seayar Mohabbat, Hanan Sinada, Yael Efraim, Feeling Yu Ting Chen, Luye An, Eliza A. Gaylord, Chelsea S. Bahney, , Sarah M. Knox

This study shows that muscarinic agonists can restore non-healing salivary glands by reactivating endogenous regeneration and mitochondrial function through cholinergic-calcium signaling.

bioRxiv · Dec 31, 2024 · PreprintCell Biology