Hafez El Sayyed

This paper introduces SPIN-Seq, a method that links DNA sequence with functional properties at the single-molecule level, revealing sequence-dependent transcription factor interactions and RNA polymerase behavior.

The paper reports the cryoEM structure of TraT, an outer membrane protein involved in plasmid exclusion, and suggests it functions by physical interference rather than specific protein interactions.

The paper uses high-speed polarization microscopy to study dynamic heterogeneity in bacterial flagellar motors, revealing complex non-classical diffusion and potential energy landscape changes.

This study uses single-molecule tracking to reveal NusG's functional allocation, interactions, and spatial organization in E. coli, showing its roles in transcription elongation, anti-termination, and coupling with translation.

This study investigates chromosome folding in E. coli with altered decatenation activities, revealing roles for Topo IV, Topo III, MatP, and MukB in sister chromatid organization.