The Spx stress regulator confers high-level β-lactam resistance and decreases susceptibility to last-line antibiotics in methicillin resistant Staphylococcus aureus
Tobias K. Nielsen, Ida Birkjær Petersen, Lijuan Xu, Maria Disen Barbuti, Viktor Hundtofte Mebus, Anni Justh, Abdulelah A. Alqarzaee, Nicolas Jacques, Cécile Oury, Vinai Chittezham Thomas, Morten Kjos, Camilla Henriksen, Dorte Frees
This study identifies Spx as a stress regulator that enhances β-lactam resistance and reduces susceptibility to last-line antibiotics in MRSA through a redox-independent mechanism.
Antimicrobial Agents and Chemotherapy · May 1, 2024Peer-reviewedMicrobiology