Author

Kevyn L. Hart

City Of Hope National Medical CenterORCID 0000-0002-7567-1744Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Alison D. TangiD· 1 shared Angela Norie BrooksiD· 1 shared Cameron M. SouletteiD· 1 shared Catherine J. WuiD· 1 shared Eva Hrabeta‐RobinsoniD· 1 shared Lei Yu· 1 shared Lili WangiD· 1 shared Marijke J. van BareniD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenomics

Alison D. TangORCID

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2 papers

Recent·Most cited

Engineering oncogenic hotspot mutations on SF3B1 via CRISPR-directed PRECIS mutagenesis

Mike Minh Fernandez, Qiong Jia, Lei Yu, Xuesong Wang, Kevyn L. Hart, Zhenyu Jia, Ren-Jang Lin, Lili Wang

This paper develops PRECIS, a method combining prime editing and a synthetic intron reporter to efficiently generate SF3B1 mutant cell lines that recapitulate cancer-related splicing and CNV events.

Cancer Research Communications · Aug 28, 2024Peer-reviewedCancer Biology

Full-length transcript characterization of SF3B1 mutation in chronic lymphocytic leukemia reveals downregulation of retained introns

Alison D. Tang, Cameron M. Soulette, Marijke J. van Baren, Kevyn L. Hart, Eva Hrabeta‐Robinson, Catherine J. Wu, Angela Norie Brooks

The paper uses nanopore sequencing to analyze full-length transcripts in CLL samples with and without SF3B1 mutations, revealing altered intron retention and splicing patterns.

Nature Communications · Mar 18, 2020Peer-reviewedGenomics