Jorge Dubcovsky

A genetic toolkit to reduce wheat immunogenicity and incidence of celiac disease

This study generates non-transgenic wheat genetic stocks with reduced immunogenic epitopes to develop celiac disease-safe wheat varieties.

Regulation of spikelet number during wheat spike development

This paper reviews gene networks regulating spikelet number in wheat and highlights recent advances in understanding and engineering spike development for improved yield.

MicroRNA156 and its targeted SPL genes interact with the photoperiod, vernalization, and gibberellin pathways to regulate wheat heading time

This study identifies miR156 and SPL genes' roles in wheat heading time regulation through interactions with photoperiod, vernalization, and gibberellin pathways, and develops genetic resources to fine-tune heading time.

Spatial and single-cell expression analyses reveal complex expression domains in early wheat spike development

Combining 99-gene smFISH across 48,225 cells with scRNA-seq of 26,009 cells maps 21 spatial expression domains and imputes 74,464 genes in early tetraploid wheat spikes.

Deletion of wheat alpha-gliadins from chromosome 6D improves gluten strength and reduces immunodominant celiac disease epitopes

This study deletes wheat alpha-gliadins from chromosome 6D to improve gluten strength and reduce celiac disease epitopes.

Manipulation of the microRNA172 - AP2L2 interaction provides precise control of wheat and triticale plant height

This study engineered the miR172-AP2L2 interaction to control wheat and triticale plant height without affecting coleoptile or first-leaf length.

Natural alleles of LEAFY and WAPO1 interact to regulate spikelet number per spike in wheat

This study identifies natural alleles of LEAFY and WAPO1 that interact to regulate spikelet number per spike in wheat, suggesting a genetic combination for improving grain yield.

Sequencing 4.3 million mutations in wheat promoters to understand and modify gene expression

The paper sequences 4.3 million promoter mutations and 4.7 million coding mutations in wheat to understand gene function and improve agronomic traits.

A second generation capture panel for cost-effective sequencing of genome regulatory regions in wheat and relatives

The paper develops an updated capture panel for sequencing regulatory regions in wheat and related species, improving specificity and coverage over previous methods.

Development of the Wheat Practical Haplotype Graph Database as a Resource for Genotyping Data Storage and Genotype Imputation

The paper develops a wheat haplotype graph database for efficient genotype storage and imputation, showing improved accuracy over existing methods.

A haplotype-phased genome of wheat stripe rust pathogen Puccinia striiformis f. sp. tritici, race PST-130 from the Western USA

The paper presents an improved haplotype-phased genome assembly of the wheat stripe rust pathogen PST-130 using long-read sequencing and diploid-aware assembly, revealing genetic diversity and potential introgression events.

Three previously characterized resistances to yellow rust are encoded by a single locus Wtk1

The paper shows that three yellow rust resistance genes in wheat are all encoded by the same locus Wtk1, but their resistance responses vary depending on genetic background.

Wheat VRN1, FUL2 and FUL3 play critical and redundant roles in spikelet development and spike determinacy

This study identifies VRN1, FUL2, and FUL3 as critical and redundant genes in wheat spikelet development, affecting flowering time, plant height, and grain yield.

A wheat/rye polymorphism affects seminal root length and is associated with drought and waterlogging tolerance