Author

Kai Otsuka

Tokyo University of ScienceORCID 0000-0002-7573-010XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:ChIP-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Satoshi H. NamekawaiD· 3 shared So MaezawaiD· 2 shared Ai IkuyoiD· 1 shared Akihiko SakashitaiD· 1 shared Akiyoshi HirayamaiD· 1 shared Anna R. Kohrs· 1 shared Hironori AbeiD· 1 shared Jasmine M. EsparzaiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersDevelopmental Biology

Satoshi H. NamekawaORCID

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3 papers

Recent·Most cited

Folate-dependent one-carbon metabolism controls meiotic and post-meiotic epigenome remodeling in the male germline

Ai Ikuyo, Nozomu Fuse, Masaru Mori, Akiyoshi Hirayama, Yuto Yamada, Tatsuya Nakamura, Tomoko Sagi, Kai Otsuka, Satoshi H. Namekawa, Tomoyoshi Soga, Yohei Hayashi, So Maezawa

This study shows folate deficiency during spermatogenesis causes stage-specific metabolic and chromatin changes in the male germline, affecting histone modifications and epigenetic inheritance.

bioRxiv · Apr 28, 2026 · PreprintDevelopmental Biology

KRAB-zinc-finger proteins regulate endogenous retroviruses to sculpt germline transcriptomes and genome evolution

Kai Otsuka, Akihiko Sakashita, So Maezawa, Richard M. Schultz, Satoshi H. Namekawa

This study shows that KRAB-zinc-finger proteins regulate endogenous retroviruses in the germline, shaping transcriptomes and genome evolution through evolutionary conserved mechanisms.

Genome Research · Mar 1, 2025Peer-reviewedGenomics

ATF7IP2/MCAF2 directs H3K9 methylation and meiotic gene regulation in the male germline

Kris G. Alavattam, Jasmine M. Esparza, Mengwen Hu, Ryuki Shimada, Anna R. Kohrs, Hironori Abe, Yasuhisa Munakata, Kai Otsuka, Saori Yoshimura, Yuka Kitamura, Yu-Han Yeh, Yueh‐Chiang Hu, Jihye Kim, Paul R. Andreassen, Kei‐ichiro Ishiguro, Satoshi H. Namekawa

This study identifies ATF7IP2 as a critical regulator of H3K9 methylation and meiotic gene regulation in male germline, showing its role in heterochromatin organization and meiotic sex chromosome inactivation.

Genes & Development · Feb 1, 2024Peer-reviewedDevelopmental Biology