Author

Erik K. Henze

Cornell UniversityORCID 0000-0002-7594-4319Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Assay:protein structure· 1

Frequent Co-Authors

Toshimitsu KawateiD· 2 shared Eric GelsleichteriD· 1 shared Hiro FurukawaiD· 1 shared Jacqueline J. EhrlichiD· 1 shared Janice RobertsoniD· 1 shared Johanna Liinamaria SyrjäneniD· 1 shared Julia M. KumpfiD· 1 shared Kevin R. Michalski· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 16 mutual co-author links

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2 shared papersBiophysics

Toshimitsu KawateORCID

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2 papers

Recent·Most cited

BiophysicsProceedings of the National Academy of SciencesPeer-reviewedDec 13, 2024

The C-terminal activating domain promotes Panx1 channel opening

Erik K. Henze, Jacqueline J. Ehrlich, Janice Robertson…·Toshimitsu Kawate

This paper identifies the C-terminal activating domain (CAD) as essential for Panx1 channel opening, showing how its cleavage repositions the N-terminus to reduce anion accumulation and promote ion permeability.

18 citationstop 3%

experimental assaycell signaling & trafficking

𝕏 PostBluesky

NeurosciencebioRxivPreprintDec 30, 2019

The Cryo-EM Structure of a Pannexin 1 Channel Reveals an Extracellular Gating Mechanism

Kevin R. Michalski, Johanna Liinamaria Syrjänen, Erik K. Henze…·Toshimitsu Kawate

The paper presents the cryo-EM structure of a pannexin 1 channel, revealing an extracellular gating mechanism and identifying key residues involved in ion selectivity and channel inhibition.

DOI 10.1101/2019.12.30.890780

protein structureexperimental assay

𝕏 PostBluesky