David S. Fay

Epidermal cell fusion promotes the transition from an embryonic to a larval transcriptome in C. elegans

The paper shows that cell fusion in C. elegans epidermis drives transcriptomic changes from embryonic to larval state, with eff-1 mutants showing delayed progression.

Proximity Labeling of NIMA Kinase Complex Components in C. elegans

This study uses proximity labeling and DIA-MS to analyze NEKL-MLT kinase complex interactions in C. elegans, identifying known and novel interactors and validating their roles in membrane trafficking and cytoskeletal regulation.

PIKI-1, a class II phosphatidylinositol 3-kinase, functions in endocytic trafficking

This study identifies PIKI-1 as a Class II PI3K essential for PI(3,4)P2 production and early endosomal function in C. elegans, showing its role in suppressing NEKL-related molting defects.

TAT-1, a phosphatidylserine flippase, affects molting and regulates membrane trafficking in the epidermis of C. elegans

This study identifies TAT-1 as a phosphatidylserine flippase required for normal endosomal function and molting in C. elegans, linking it to NEKL-2/3 and endocytic processes.

Loss of the Na+/K+ cation pump CATP-1 suppresses nekl-associated molting defects

The paper identifies catp-1 as a suppressor of molting defects in nekl-2; nekl-3 mutants in C. elegans, suggesting it modulates membrane trafficking by altering electrochemical gradients.

A conserved protein tyrosine phosphatase, PTPN-22, functions in diverse developmental processes in C. elegans

This study identifies novel functions of the conserved phosphatase PTPN-22 in C. elegans, showing its role in molting, cell adhesion, and cytoskeletal regulation through genetic and proteomic analyses.

Pathways that affect anterior morphogenesis in C. elegans embryos

The paper identifies new proteins involved in apical ECM biology in C. elegans and shows SYM-3/FAM102A and SYM-4/WDR44 function in trafficking but not ECM protein deposition.

An unexpected role for the conserved ADAM-family metalloprotease ADM-2 in Caenorhabditis elegans molting

This paper identifies ADM-2 as a negative regulator of molting in C. elegans, showing it inhibits molting by regulating LRP-1 and endocytic trafficking.

A life cycle alteration can correct molting defects in Caenorhabditis elegans

The paper shows that transitioning through the L2d stage can rescue molting defects in C. elegans with reduced NEKL function by restoring transcriptional defects associated with molting.

Multi-tissue patterning drives anterior morphogenesis of the C. elegans embryo

The paper studies how three tissue types coordinate during anterior lumen formation in C. elegans embryos using microscopy and software analysis.

Use of a Sibling Subtraction Method (SSM) for Identifying Causal Mutations in C. elegans by Whole-Genome Sequencing

The paper introduces the Sibling Subtraction Method (SSM) to identify causal mutations in C. elegans using whole-genome sequencing, showing it reduces candidate mutations effectively.