Jakob Franke

THEOBROMA: an aggregated open database of 1.13 million natural products with per-compound license auditing, three-tier classification, and stereochemistry-aware deduplication

THEOBROMA aggregates 1.13 million natural products with per-compound license auditing, three-tier classification, and stereochemistry-aware deduplication to support license-compatible virtual screening and bioactivity analysis.

Production of the anticancer drug intermediate strictosidinic acid in engineered yeast

This paper engineers yeast to produce strictosidinic acid, a key anticancer drug intermediate, achieving 548 mg/L through metabolic pathway optimization and strain engineering.

Phylogenomics and metabolic engineering reveal a conserved gene cluster in Solanaceae plants for withanolide biosynthesis

Comparing nine Solanaceae genomes reveals a conserved withanolide gene cluster; three of its P450s, expressed in yeast and N. benthamiana, oxidise 24-methyldesmosterol toward the withanoside V aglycone.