Giulia Callegaro

Systematic assessment of transcriptomic and phenotypic biological profiling for mechanism-based hazard assessment using target-annotated reference chemicals in renal proximal tubular epithelial cells

This study evaluates transcriptomic and morphological profiling methods for hazard assessment using reference chemicals in renal cells, finding HTTr provides higher mechanistic resolution than CPP.

Cell Painting PLUS expands morphological profiling to enhance mechanistic understanding of compounds

The paper evaluates Cell Painting (CP) and Cell Painting PLUS (CPP) for predicting compound mechanisms of action, finding CPP better resolves off-target effects and improves MoA prediction for lysosome-related compounds.

Cell Painting PLUS reveals phenotypic signatures for nephrotoxicity profiling in human RPTEC/TERT1

This study uses Cell Painting PLUS to identify nephrotoxicity-related morphological signatures in human RPTEC/TERT1 cells by analyzing over 300 compounds.

Analytical Choices Drive Toxicogenomic Potency Estimates: A Systematic Evaluation of Transcriptomic Points of Departure

The paper evaluates how different transcriptomic analysis workflows affect potency estimates in toxicogenomics, finding significant variability driven by normalization, filtering, and pathway definitions.