Gerhard Franz Ecker

This study evaluates transcriptomic and morphological profiling methods for hazard assessment using reference chemicals in renal cells, finding HTTr provides higher mechanistic resolution than CPP.

The paper evaluates Cell Painting (CP) and Cell Painting PLUS (CPP) for predicting compound mechanisms of action, finding CPP better resolves off-target effects and improves MoA prediction for lysosome-related compounds.

This study uses Cell Painting PLUS to identify nephrotoxicity-related morphological signatures in human RPTEC/TERT1 cells by analyzing over 300 compounds.

PharmAverse provides an interactive dashboard for analyzing and visualizing adverse event data using MedDRA terms, offering views on adverse events, drugs, and targets.

The paper creates a functional landscape of human solute carriers by integrating multi-omics data and curated knowledge, assigning functions to each SLC and providing a web-accessible resource.

The paper identifies mutation hotspots in SLC6 transporters linked to clinical pathogenicity by analyzing protein-protein interactions and structural data.

The paper uses proteochemometric modeling to identify amino acids critical for GABA transporter subtype selectivity.