José M. Muiño

Cell Painting PLUS expands morphological profiling to enhance mechanistic understanding of compounds

The paper evaluates Cell Painting (CP) and Cell Painting PLUS (CPP) for predicting compound mechanisms of action, finding CPP better resolves off-target effects and improves MoA prediction for lysosome-related compounds.

Cell Painting PLUS reveals phenotypic signatures for nephrotoxicity profiling in human RPTEC/TERT1

This study uses Cell Painting PLUS to identify nephrotoxicity-related morphological signatures in human RPTEC/TERT1 cells by analyzing over 300 compounds.

ARABIDOPSIS Bsister and SEEDSTICK MADS-box transcription factors modulate maternal nutrient flow for seed development in Arabidopsis

The paper identifies MIKC MADS-box transcription factors ABS/TT16 and STK as regulators of maternal nutrient flow during ovule maturation and seed development in Arabidopsis.

The role of FRUITFULL controlling cell cycle during early flower development revealed by time series snRNA-seq experiments.

The paper uses time-series snRNA-seq to study flower development in Arabidopsis, identifying FUL's regulation of KRP2 as a key bifurcation point between cell cycle and developmental programs.

Single-nuclei RNA-sequencing of plant tissues

This paper introduces a nuclei isolation method for plant tissues followed by single-nuclei RNA-seq, enabling transcriptome analysis of various plant species and tissues.

Chromatin-release of the long ncRNA A-ROD is required for transcriptional activation of its target gene DKK1

The paper identifies A-ROD as a long ncRNA that requires chromatin-release to activate DKK1 transcription by recruiting EBP1 to the promoter.