Meleana M. Hinchman

High-resolution spatial transcriptomics maps viral tropism and reveals spatially organized immune modules in viral encephalitis

This study uses high-resolution spatial transcriptomics to map viral tropism and immune responses in neonatal mouse brains infected with reovirus, revealing spatial patterns of infection and immune module organization.

A single point mutation in the σ3 protein encoded by the reovirus S4 gene substantially attenuates the virulence of a highly myocarditic reassortant virus in neonatal mice

This study shows that a single point mutation in the σ3 protein of a reovirus reduces virulence and myocarditis in neonatal mice by enhancing innate immune responses.

Spatiotemporal transcriptomics reveals pathogenesis of viral myocarditis

This study uses spatiotemporal transcriptomics to map reovirus-induced myocarditis in neonatal mice, revealing immune responses and cellular interactions in the heart and intestine.

In situ polyadenylation enables spatial mapping of the total transcriptome

This paper introduces a method to spatially map the total transcriptome by enabling detection of non-polyadenylated RNAs through in situ polyadenylation.

Simultaneous multiplexed amplicon sequencing and transcriptome profiling in single cells

This paper introduces DART-seq, a method that enables multiplexed amplicon sequencing and transcriptome profiling in single cells, applied to study viral transcripts and B cell immune repertoires.