Danica M. Sutherland

The paper reports the cryo-EM structure of piscine orthoreovirus, showing structural conservation with mammalian orthoreoviruses despite low sequence identity.

This study uses high-resolution spatial transcriptomics to map viral tropism and immune responses in neonatal mouse brains infected with reovirus, revealing spatial patterns of infection and immune module organization.

This study shows a single amino acid change in a reovirus alters its infection outcome in mice with microbiota depletion, affecting tropism and sensitivity to microbiota-driven antiviral responses.

This study identifies Cmas and Slc35a1 as host factors required for reovirus binding and infection in murine microglial cells by mediating sialic acid expression.