Christine L. Lavoie

This study shows that SNX2, but not SNX1, regulates MET endosomal trafficking and signaling in HCT116 cells, leading to enhanced AKT activation and poorer CRC patient survival.

This study investigates the K53N mutation in Gs isoforms, revealing isoform-specific loss- and gain-of-function effects contributing to disease mechanisms in endocrine and cardiac tissues.

This study shows that SNX1 and SNX2 regulate MET trafficking, affecting phosphorylation of MET and AKT but not ERK1/2, and influence apoptosis resistance in CRC cells.