Sergio Menchero

This study uses CRISPR-Cas9 in opossums to show RSX is required for initiating X-inactivation, with divergent Polycomb regulation compared to eutherians.

This study generates the first single-cell transcriptomic atlas of marsupial gastrulation and early organogenesis, revealing accelerated transcriptional programs and novel tissues associated with developmental heterochrony.

This study shows sex chromosomes significantly shape the transcriptional landscape of preimplantation mouse embryos through various mechanisms including Y chromosome effects, X chromosome dosage, imprinting, and Xist.

This study identifies Nanog as a repressor of Pou3f1, which inhibits anterior neural fate during gastrulation in mouse embryos.

This study identifies Notch's role in driving cell potency transitions during early mouse development, revealing novel targets and interactions with Hippo signaling.