Retinoid X receptor alpha is a spatiotemporally-specific therapeutic target for doxorubicin-induced cardiomyopathy in adult zebrafish
Xiao Ma, Yonghe Ding, Hong Zhang, Qi Qiu, Alexey V. Dvornikov, Maengjo Kim, Yong Wang, Matthew R. Lowerison, Joerg Herrmann, Stephen Carl Ekker, Tzung K. Hsiai, Xueying Lin, Xiaolei Xu
This study identifies RXRA as a therapeutic target for doxorubicin-induced cardiomyopathy in zebrafish by showing its endothelial-specific function and response to FDA-approved agonists.
bioRxiv · Dec 8, 2018 · PreprintGenetics