Tzung K. Hsiai

This paper introduces NIR-II squeezed light-field microscopy to enable high-speed volumetric imaging of deep-tissue dynamics in vivo, achieving 600 volumes per second with high resolution.

This study identifies the IRE1-Xbp1-Vimp/Rpn2 axis as a regulator of differential growth between left and right ventricles during postnatal development by modulating cardiomyocyte proliferation, hypertrophy, and apoptosis.

The paper shows that atrial peristalsis drives the transition from a bicuspid to quadricuspid valve in zebrafish through Klf2a-Snai1b signaling and shear stress alignment.

This study shows photoaged microplastics impair endothelial calcium signaling and vascular integrity by disrupting Piezo1-Notch mechanotransduction.

This paper introduces squeezed light field microscopy (SLIM), a method for high-speed 3D volumetric imaging, and demonstrates its application in tracking blood cell motion and neural activity in vivo.

This paper develops a rapid, specific, and reusable DNA aptamer-based biosensor for detecting SARS-CoV-2 spike protein, demonstrating high sensitivity and structural insights through cryo-EM.

The paper shows that vascular injury leads to changes in vessel network topology to increase blood flow and activate Notch-ephrinb2 signaling for microcirculation restoration.

This study identifies RXRA as a therapeutic target for doxorubicin-induced cardiomyopathy in zebrafish by showing its endothelial-specific function and response to FDA-approved agonists.