Tatyana Sandalova

The paper decodes correlated dynamics at the pMHC interface to understand TCR recognition and immunogenicity using computational methods.

The paper investigates MALT1 activation dynamics using a combination of AlphaFold, MD simulations, and NMR analyses, revealing how ionic strength influences its conformational states.

This study develops DARPin T cell engagers that specifically target HLA/peptide complexes on tumor cells, showing high affinity and specificity through in vitro selection and structural analysis.

The paper combines AlphaFold, MD simulations, and NMR relaxation data to identify biologically relevant protein conformational ensembles for a specific bacterial protein.

This study investigates how mutations in hKYAT1 affect its transamination and β-elimination activities across various substrates, identifying key residues that influence enzyme function.

The paper determines the crystal structure of PsrSp and uses NMR to analyze its dynamics, showing that four long loops contribute to ligand specificity through their mobility.

The paper investigates the dynamic behavior of MALT1 using NMR and AlphaFold to reveal interdomain motions involved in allosteric regulation.