Structure and autoregulation of a P4-ATPase lipid flippase
Milena Timcenko, Joseph Anthony Lyons, Dovile Januliene, Jakob Jensen Ulstrup, Thibaud Dieudonné, Cédric Montigny, Miriam-Rose Ash, Jesper Lykkegaard Karlsen, Thomas P. Boesen, Werner Kühlbrandt, Guillaume Lenoir, Arne Moeller, Poul Nissen
The paper determines the structures of the P4-ATPase Drs2p-Cdc50p using cryo-EM, revealing autoinhibition and PI4P-dependent activation mechanisms.
Nature · Jun 26, 2019Peer-reviewedMolecular Biology