Suppressing STAT3 activity protects the endothelial barrier from VEGF-mediated vascular permeability
Li Wang, Matteo Astone, Sk. Kayum Alam, Zhu Zhu, Wuhong Pei, David A. Frank, Shawn Michael Burgess, Luke H. Hoeppner
This study shows that inhibiting STAT3 reduces VEGF-induced vascular permeability in zebrafish, mice, and human endothelium, suggesting a therapeutic target for diseases involving vascular leakage.
Disease Models & Mechanisms · Sep 20, 2021Peer-reviewedMolecular Biology