Molecular BiologyDisease Models & MechanismsPeer-reviewed
Suppressing STAT3 activity protects the endothelial barrier from VEGF-mediated vascular permeability
Li Wang, Matteo Astone, Sk. Kayum Alam…·Luke H. Hoeppner
This study shows that inhibiting STAT3 reduces VEGF-induced vascular permeability in zebrafish, mice, and human endothelium, suggesting a therapeutic target for diseases involving vascular leakage.