Li Wang

This study shows that primary cilia formation contributes to resistance to osimertinib in EGFR-mutated NSCLC by promoting sodium influx and HDAC6 inactivity, and that targeting ciliogenesis can reverse resistance.

This study shows that loss of miR-153 promotes EndMT in lung endothelial cells, leading to vascular permeability and remodeling in pulmonary hypertension.

The paper identifies LxxLL motifs in NIPBL that regulate its interaction with MAU2 and steroid receptors, forming a ternary complex with GR to facilitate enhancer localization of cohesin.

This study establishes a hairless mouse model of radiation dermatitis that mimics human disease, showing severe skin injury and specific histopathological markers for preclinical research.

The paper demonstrates the synthesis of modified lysines and their use in creating a system to specifically label NSUN2, enabling precise regulation and fluorescent labeling of the enzyme.

This study shows that inhibiting STAT3 reduces VEGF-induced vascular permeability in zebrafish, mice, and human endothelium, suggesting a therapeutic target for diseases involving vascular leakage.

The paper identifies RPAP2 as a gatekeeper that prevents preinitiation complex assembly by blocking Pol II-TFIIF interaction, thereby regulating transcription initiation.