Luke H. Hoeppner

This study shows that primary cilia formation contributes to resistance to osimertinib in EGFR-mutated NSCLC by promoting sodium influx and HDAC6 inactivity, and that targeting ciliogenesis can reverse resistance.

This study shows that loss of miR-153 promotes EndMT in lung endothelial cells, leading to vascular permeability and remodeling in pulmonary hypertension.

The paper shows pyrimethamine, an FDA-approved drug, reduces vascular permeability and mycobacterial burden in a zebrafish infection model by inhibiting bacterial dihydrofolate reductase and restoring vascular barrier function.

This study shows that dopamine D2 receptor agonists reduce angiogenesis and inhibit chemotherapy-refractory small cell lung cancer progression by targeting tumour-associated endothelial cells.

This study establishes a hairless mouse model of radiation dermatitis that mimics human disease, showing severe skin injury and specific histopathological markers for preclinical research.

This study shows that inhibiting STAT3 reduces VEGF-induced vascular permeability in zebrafish, mice, and human endothelium, suggesting a therapeutic target for diseases involving vascular leakage.

The paper evaluates image quality in scientific publications, identifying common issues and providing guidelines to improve clarity and accessibility.

This study shows that VEGF signaling is activated by UV exposure and that inhibiting it can prevent sunburn symptoms in mice, suggesting a new therapeutic approach for UV-induced skin damage.