Author

Hui‐Hsin Tsai

Biogen (United States)ORCID 0009-0009-7337-4250Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:spatial transcriptomics· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1 Assay:CRISPR screen· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Baohong ZhangiD· 2 shared Patrick F. Cullen· 2 shared Sarbottam PiyaiD· 2 shared Su Jing ChaniD· 2 shared Taylor L. ReynoldsiD· 2 shared Thomas M. CarlileiD· 2 shared Wenxing HuiD· 2 shared Amanda J. GuiseiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersNeuroscience

Baohong ZhangORCID

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3 papers

Recent·Most cited

NeuroscienceFrontiers in BioinformaticsPeer-reviewedAug 6, 2026

Spatial transcriptomics reveals heterogeneous cell-cell interactions among brain regions in a cuprizone model consistent with multiple sclerosis lesions

Hui‐Hsin Tsai, Sarbottam Piya, Jing Wang…·Baohong Zhang

The paper uses spatial transcriptomics to analyze cell-cell interactions in a cuprizone model, finding region-specific changes and partial translatability to multiple sclerosis lesions.

DOI 10.3389/fbinf.2026.1832826

mousespatial transcriptomics

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GenomicsNature MethodsPeer-reviewedSep 1, 2025

Scaling up spatial transcriptomics for large-sized tissues: uncovering cellular-level tissue architecture beyond conventional platforms with iSCALE

Amelia R. Schroeder, Melanie Loth, Chunyu Luo…·Mingyao Li

iSCALE predicts super-resolution gene expression and annotates tissue architecture in large tissues, revealing features missed by conventional spatial transcriptomics.

31 citationstop 1%

humanspatial transcriptomics

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NeurosciencePLoS GeneticsPeer-reviewedApr 29, 2021

Phenotypic screening using synthetic CRISPR gRNAs reveals pro-regenerative genes in spinal cord injury

Marcus Keatinge, Themistoklis M. Tsarouchas, Tahimina Munir…·Thomas Becker

The paper uses synthetic CRISPR gRNAs and in vivo pre-screening to identify pro-regenerative genes in spinal cord injury, finding that tgfb1a promotes regeneration by controlling inflammation.

75 citationstop 2%

zebrafishCRISPR screen

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