MicrobiologybioRxivPreprint
Pyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification
Janïs Laudouze, Tatyana I. Rokitskaya, Akira Abolet…·Pierre Santucci
This study investigates the mechanism of action of pyrazinamide (PZA) in Mycobacterium tuberculosis, showing it kills bacteria by acidifying cytosol via pH-driven weak-acid permeation, independent of PanD and pantothenate levels.
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