Author

Alexandre Gouzy

Weill Cornell MedicineORCID 0000-0001-6671-7408Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Sabine EhrtiD· 2 shared A. M. SalehiD· 1 shared Akira Abolet· 1 shared Alain R. BaulardiD· 1 shared Alexander M. FirsoviD· 1 shared Allen NaiD· 1 shared Ananya NaickiD· 1 shared Claire M. HealyiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

Sabine EhrtORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

MicrobiologybioRxivPreprintMar 16, 2026

Non-canonical peptidoglycan cross-linking is essential for Mycobacterium tuberculosis acid resistance

Ruoyao Ma, Daniel Rea, Karl L. Ocius…·Sabine Ehrt

This study identifies LdtB as essential for Mycobacterium tuberculosis acid resistance by linking peptidoglycan cross-linking to intrabacterial pH homeostasis and antibiotic susceptibility.

1 citation

experimental assayhost-pathogen & immune response

𝕏 PostBluesky

MicrobiologybioRxivPreprintMar 10, 2026

Metabolic control of drug resistance by a mycobacterial ion channel

Alexandre Gouzy, Shuqi Li, James Chen…·Jeremy M. Rock

The paper identifies Rv2571c as a mycobacterial ion channel that mediates pyrazinamide resistance by regulating cytoplasmic acidification.

1 citation

metabolomicsgenetic perturbation / CRISPR

𝕏 PostBluesky

MicrobiologybioRxivPreprintSep 26, 2025

Pyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification

Janïs Laudouze, Tatyana I. Rokitskaya, Akira Abolet…·Pierre Santucci

This study investigates the mechanism of action of pyrazinamide (PZA) in Mycobacterium tuberculosis, showing it kills bacteria by acidifying cytosol via pH-driven weak-acid permeation, independent of PanD and pantothenate levels.

5 citations

humanproteomics

𝕏 PostBluesky