Author

Janïs Laudouze

Centre National de la Recherche Scientifique

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Organism:bacteria (other)· 1 Research Focus:clustering· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

Pierre SantucciiD· 5 shared Stéphane CanaaniD· 5 shared Céline CrausteiD· 4 shared Vanessa Point· 4 shared Wafaa Achache· 3 shared Eliana Sepulveda Ramos· 2 shared Gabriela GagoiD· 2 shared Jean‐François CavalieriD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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5 shared papersMicrobiology

Pierre SantucciORCID

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Author profile →

5 papers

Recent·Most cited

Development of inducible genetic systems to finely tune efficacy of InhA-targeting anti-tuberculous drugs

Eliana Sepulveda Ramos, Maria Sofia Deschutter, Vanessa Point, Thibault Brunet, Janïs Laudouze, Wafaa Achache, Céline Crauste, Stéphane Canaan, Gabriela Gago, Mickaël Maziero, Pierre Santucci

This paper develops CRISPRi-based inducible systems to fine-tune antibiotic susceptibility in Mycobacterium tuberculosis by targeting key genes involved in drug activation.

bioRxiv · Oct 7, 2026 · PreprintMicrobiology

Mycobacterial cell division arrest and smooth-to-rough envelope transition using CRISPRi-mediated genetic repression systems

Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci

This paper describes a CRISPRi-based protocol to assess gene silencing and envelope transitions in Mycobacterium smegmatis as a model for NTM pathogenesis.

FEBS Open Bio · Nov 30, 2025Peer-reviewedMicrobiology

Pyrazinamide kills Mycobacterium tuberculosis via pH-driven weak-acid permeation and cytosolic acidification

Janïs Laudouze, Tatyana I. Rokitskaya, Akira Abolet, Vanessa Point, Alexander M. Firsov, Ljudmila S. Khailova, Maria Sofia Deschutter, Gabriela Gago, Jean‐François Cavalier, Stéphane Canaan, Alain R. Baulard, Yuri N. Antonenko, Alexandre Gouzy, Pierre Santucci

This study investigates the mechanism of action of pyrazinamide (PZA) in Mycobacterium tuberculosis, showing it kills bacteria by acidifying cytosol via pH-driven weak-acid permeation, independent of PanD and pantothenate levels.

bioRxiv · Sep 26, 2025 · PreprintMicrobiology

Anti-tubercular potential and pH-driven mode of action of salicylic acid derivatives

Janïs Laudouze, Thomas Francis, Emma Forest, Frédérique Mies, Jean‐Michel Bolla, Céline Crauste, Stéphane Canaan, Vadim Gh. Shlyonsky, Pierre Santucci, Jean‐François Cavalier

The paper evaluates the antimycobacterial activity of salicylic acid derivatives and shows they disrupt intrabacterial pH homeostasis in M. tuberculosis.

FEBS Open Bio · Dec 3, 2024Peer-reviewedMicrobiology

Fluorescence-based CRISPR interference system for controlled genetic repression and live single-cell imaging in mycobacteria

Janïs Laudouze, Vanessa Point, Wafaa Achache, Céline Crauste, Stéphane Canaan, Pierre Santucci

The paper develops and validates fluorescence-based CRISPRi tools for gene repression and live single-cell imaging in mycobacteria.

FEBS Letters · Dec 1, 2024Peer-reviewedMicrobiology