Subanesthetic Ketamine Disrupts Predictive Signaling in the Prefrontal Cortex
Benjamin W. Corrigan, Megan P. Roussy, Rogelio Luna, Roberto A. Gulli, Jeffrey D. Schall, Adam J. Sachs, Lena K. Palaniyappan, Julio Martínez-Trujillo
This study shows that subanesthetic ketamine disrupts corollary discharge signaling in the prefrontal cortex of macaques, impairing predictive mechanisms linked to schizophrenia.
bioRxiv · Nov 24, 2025 · PreprintNeuroscience