Hydrostatic pressure shapes and canalizes semicircular canal morphology to ensure vestibular function
Jiacheng Wang, Kira L. Heikes, Yufei Wu, Anne Belle Briggs, Kevin Li, Nadia Eliora, Srihas Surapaneni, Roarke W. Horstmeyer, Michel Bagnat, Akankshi Munjal
The paper shows hydrostatic pressure from the inflating otic vesicle shapes zebrafish semicircular canals, driving pillars toward a common geometry and ensuring vestibular function.
bioRxiv · Jul 23, 2026 · PreprintDevelopmental Biology