Lukáš Kubala

Multi-Objective Engineering of Fibrin-Selective Thrombolytic Proteases with Enhanced Biocatalytic Efficiency and Inhibition Resistance

This paper designs next-generation thrombolytic proteases with improved catalytic efficiency, fibrin selectivity, and inhibition resistance through multi-objective enzyme engineering.

Bacterial Stimulation Remodels Macrophage Extracellular Vesicle Lipids and Reveals iNOS as an Inflammatory Cargo

This study shows bacterial stimulation changes macrophage-derived extracellular vesicle lipid composition and identifies iNOS as an active inflammatory cargo in these vesicles.

Biochemical and Immunological Properties of Engineered Low-Immunogenic Staphylokinases for Next-Generation Thrombolytic Therapy

The paper compares biochemical and immunological properties of engineered low-immunogenic staphylokinase variants to identify the most promising for thrombolytic therapy.

Characterization of a chronic UV-induced photoaging mouse model: insights into skin barrier dysfunction, extracellular matrix remodeling, and altered adipogenesis

This study characterizes a chronic UV-induced photoaging mouse model, showing reduced HA content, altered DNA repair, and increased adipogenesis over eight weeks.