Author

Riccardo E. Mezzadra

Memorial Sloan Kettering Cancer CenterORCID 0000-0002-7737-8461Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Cole P MartiniD· 1 shared David L. CorcoraniD· 1 shared Deena M ScovilleiD· 1 shared Jacqueline A. BrinkmaniD· 1 shared Jesse R. RaabiD· 1 shared John P. MorrisiD· 1 shared Jossie J. Yashinskie· 1 shared Lydia W.S. FinleyiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperCancer Biology

Cole P MartinORCID

Mutual co-authors in cluster

Author profile →

1 paper

Recent·Most cited

Mutant IDH uncouples p53 from target gene regulation to disable tumor suppression

Cole P Martin, William B. Sullivan, Jacqueline A. Brinkman, Deena M Scoville, Jossie J. Yashinskie, Sha Tian, Riccardo E. Mezzadra, Yu-Jui Ho, Richard P. Koche, Timour Baslan, Jesse R. Raab, David L. Corcoran, Lydia W.S. Finley, Scott W. Lowe, John P. Morris

This paper shows that mutant IDH disrupts p53 target gene regulation by altering chromatin states, disabling tumor suppression, and that this effect can be reversed with IDH inhibition.

bioRxiv · Sep 30, 2024 · PreprintCancer Biology