Jacqueline A. Brinkman

Loss of cBAF Complex Confers Sorafenib Resistance in Liver Cancer

This study identifies the cBAF complex as a driver of sorafenib resistance in liver cancer by disrupting hepatocyte lineage identity and promoting a mesenchymal drug-tolerant state.

Menin-MLL1 complex cooperates with NF-Y to promote HCC survival

This study identifies the menin-MLL1 complex as essential for HCC survival and shows it cooperates with NF-Y to regulate oncogenic gene transcription.

Mutant IDH uncouples p53 from target gene regulation to disable tumor suppression

This paper shows that mutant IDH disrupts p53 target gene regulation by altering chromatin states, disabling tumor suppression, and that this effect can be reversed with IDH inhibition.