Jossie J. Yashinskie

This study shows p53 enables lipid headgroup recycling during senescence by increasing phosphoethanolamine supply through autophagy and lysosomal catabolism, revealing a metabolic vulnerability in p53-activated cells.

This paper shows that mutant IDH disrupts p53 target gene regulation by altering chromatin states, disabling tumor suppression, and that this effect can be reversed with IDH inhibition.