David L. Corcoran

This study shows that chromatin architecture and physical constriction together drive phenotype switching and metastasis in melanoma by altering CTCF positioning and heterochromatin structure.

The paper updates a polygenic index repository with more phenotypes, datasets, and improved causal inference methods, enhancing predictive performance and interpretability.

The paper presents a genomic data resource from a caloric restriction trial, including SNP genotypes and multi-omic longitudinal data from multiple tissues.

This paper shows that mutant IDH disrupts p53 target gene regulation by altering chromatin states, disabling tumor suppression, and that this effect can be reversed with IDH inhibition.

The paper demonstrates that TRAIL-loaded exosomes from induced neural stem cells effectively target and kill brain cancer cells in vitro and in vivo.

This study compares feature selection methods and machine learning algorithms to develop a DNA methylation-based telomere length estimator, finding that principal component analysis followed by elastic net regression performs best.

The paper develops DNAmFitAge, a biological age indicator that integrates physical fitness metrics with epigenetic clocks to assess aging and health risks.

This study analyzes DNA methylation changes in humans undergoing calorie restriction, finding CR-induced DNAm changes opposite BMI and smoking associations and aligned with aging-related CpG sites.

The paper identifies genetic variants influencing DNA methylation in blood and shows their associations with complex traits and diseases, but finds limited direct causality.

The paper constructs polygenic indexes for 47 phenotypes across 11 datasets and provides a tool to correct errors-in-variables bias when using PGIs as proxies for the additive SNP factor.

This study identifies 157 genome-wide significant loci associated with non-cognitive contributions to educational attainment, explaining 57% of genetic variance.

This paper identifies DNA methylation sites associated with aggression through a meta-analysis of epigenome-wide studies across different age groups and tissues.

The paper develops a DNA methylation-based blood test, DunedinPoAm, to quantify individual differences in the pace of biological aging and validates its association with aging-related outcomes across multiple studies.

This study examines how maternal and child genetic data relate to parenting and children's educational attainment, finding genetic and environmental interactions.

The paper links neighborhood data with genetic and social outcomes to assess whether neighborhood effects on health and behavior are due to selection or causation.

The paper finds that a polygenic score for educational attainment is associated with larger brain size and better cognitive test performance, suggesting a genetic link between brain size and intelligence.