James E. Gomez

This paper identifies a novel small-molecule inhibitor of Mycobacterium tuberculosis Pks13 through chemical-genetic interaction profiling and validates its mechanism of action.

This paper introduces a CRISPRi-based PROSPECT platform for drug discovery in M. abscessus, identifying new compound targets and revealing unexpected susceptibility to isoniazid.

This study identifies two inhibitors of the Mtb efflux pump EfpA, determines their binding mechanisms, and suggests their potential for combination anti-tuberculosis therapy.

This study creates a single-nucleus and spatial transcriptomic atlas of the COVID-19 liver, revealing cellular and functional disruptions associated with organ damage.

This paper introduces PCL analysis to predict small molecule mechanisms of action in Mycobacterium tuberculosis using PROSPECT data, achieving high sensitivity and precision in MOA prediction.

This study creates a single-cell and spatial atlas of autopsy tissues from COVID-19 patients, revealing altered cellular responses and potential therapeutic targets.