Author

Austin N. Bond

Broad InstituteORCID 0009-0001-8486-0619Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:drug response / drug discovery· 3 Approach:deep learning· 2 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:multiple species· 1 Assay:proteomics· 1

Frequent Co-Authors

Deborah Tan HungiD· 3 shared James E. GomeziD· 3 shared Diana K. HuntiD· 2 shared Emily Gath· 2 shared Ishay Ben-ZioniD· 2 shared Matthew Y. Solomon· 2 shared Noam Shoresh FiD· 2 shared Shuting ZhangiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersMicrobiology

Deborah Tan HungORCID

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3 papers

Recent·Most cited

MicrobiologyACS Infectious DiseasesPeer-reviewedMay 13, 2026

Large-Scale Chemical-Genetic Interaction Profiling Identifies a Novel Small-Molecule Inhibitor of Mycobacterium tuberculosis Polyketide Synthase 13

James E. Gomez, Matthew Y. Solomon, Diana K. Hunt…·Deborah Tan Hung

This paper identifies a novel small-molecule inhibitor of Mycobacterium tuberculosis Pks13 through chemical-genetic interaction profiling and validates its mechanism of action.

DOI 10.1021/acsinfecdis.6c00136

humanproteomics

𝕏 PostBluesky

MicrobiologyACS Infectious DiseasesPeer-reviewedOct 27, 2025

A multiplexed, target-based phenotypic screening platform using CRISPR interference in Mycobacterium abscessus

Donavan Marcus Neo, Ishay Ben-Zion, Josephine Bagnall…·Deborah Tan Hung

This paper introduces a CRISPRi-based PROSPECT platform for drug discovery in M. abscessus, identifying new compound targets and revealing unexpected susceptibility to isoniazid.

DOI 10.1021/acsinfecdis.5c00623

multiple speciesgenetic perturbation / CRISPR

𝕏 PostBluesky

MicrobiologybioRxivPreprintFeb 15, 2025

Reference-based chemical-genetic interaction profiling to elucidate small molecule mechanism of action in Mycobacterium tuberculosis

Austin N. Bond, Marek Orzechowski, Shuting Zhang…·Deborah Tan Hung

This paper introduces PCL analysis to predict small molecule mechanisms of action in Mycobacterium tuberculosis using PROSPECT data, achieving high sensitivity and precision in MOA prediction.

2 citations

deep learningdrug response / drug discovery

𝕏 PostBluesky