Andrea Cerutti

The paper identifies distinct gene signatures in effector T cells from poorly perfused tumor regions, showing enhanced IFN response and reduced PD-1 expression.

This study shows that the spleen produces neutrophils with distinct differentiation trajectories during stress, which are functionally competent and necessary for host defense against bacterial infection.

This study identifies AIRE as a checkpoint in germinal center B cells that limits antibody diversification by inhibiting AID function, leading to autoimmunity and impaired immune responses.