Involvement of the cellular prion protein in seeding and spreading of sarkosyl-derived fractions of Alzheimer's disease in Prnp mutant mice and in the P301S transgenic tauopathy mice model
Julia Sala‐Jarque, Vanessa Gil, Pol Andrés‐Benito, Laia Lidón, Renato Eduardo Yanac-Huertas, Clara F. López-León, Félix Hernández, Jesús Ávila, José Luis Lanciego, Jordi Soriano, Mario Nuvolone, Adriano Aguzzi, Rosalina Gavı́n, Isidró Ferrer, José Antonio del Rı́o
This study investigates the role of cellular prion protein in tau seeding and spreading using Prnp mutant mice and P301S tauopathy models, finding it significant in the latter but not in Alzheimer's sarkosyl-derived samples.
bioRxiv · Jan 20, 2024 · PreprintNeuroscience