Jesús Ávila

MIF-induced CD74+ microglia/macrophages are clinically relevant disease-associated subpopulations in brain metastasis and other CNS disorders

The paper identifies CD74+ microglia/macrophages driven by MIF as clinically relevant subpopulations in brain metastasis and other CNS disorders, showing their role in disease progression and therapeutic targeting potential.

The role of folate receptor α in the partial rejuvenation of dentate gyrus cells. Improvement of cognitive function in elderly mice

This study shows that folate improves cognitive function in elderly mice by partially rejuvenating dentate gyrus cells through FR activation and increased expression of juvenile genes.

Involvement of the cellular prion protein in seeding and spreading of sarkosyl-derived fractions of Alzheimer's disease in Prnp mutant mice and in the P301S transgenic tauopathy mice model

This study investigates the role of cellular prion protein in tau seeding and spreading using Prnp mutant mice and P301S tauopathy models, finding it significant in the latter but not in Alzheimer's sarkosyl-derived samples.

Lamivudine (3TC), a nucleoside reverse transcriptase inhibitor, prevents the neuropathological alterations present in mutant tau transgenic mice

This study shows that lamivudine reduces tauopathy-related pathology and behavioral deficits in P301S mice by inhibiting LINE-1 retrotransposition.

Cognitive and GABAergic protection by hAPPSw,Ind and hTauVLW coexpression: a model of Non-Demented with Alzheimer's disease Neuropathology

The paper identifies J20/VLW mice as a model for NDAN, showing preserved cognition and GABAergic pathways despite Aβ and P-Tau accumulation.

Autosomal Recessive Alzheimer disease (arAD): homozygosity mapping of genomic regions containing arAD loci

This study identifies increased homozygosity in Alzheimer's disease cases and detects a candidate recessive variant associated with amyloid metabolism.