Yan Chen

Microbial Tryptophan Metabolism Activates Host Lysosomal Activity to Facilitate Lipid Breakdown and Ameliorate Hepatic Steatosis

This study identifies how bacterial tryptophan metabolism activates lysosomal function to promote lipid breakdown and reduce hepatic steatosis in both C. elegans and mice.

Pulmonary B cells ameliorate Alzheimer's disease-like neuropathology

This study shows that pulmonary B cells reduce Alzheimer's disease-like pathology in mice by decreasing beta-amyloid production and improving cognitive function.