Author

Ruyi Xue

Shanghai Medical College of Fudan UniversityORCID 0000-0002-7785-7112Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Ge ZhangiD· 1 shared Guanxing PaniD· 1 shared Haoxuan ZhongiD· 1 shared Hu HuiD· 1 shared Jianjun Zhang· 1 shared Jianzeng DongiD· 1 shared Lin ChangiD· 1 shared She CheniD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperPharmacology & Toxicology

Ge ZhangORCID

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1 paper

Recent·Most cited

ER stress-induced TREM2 downregulation exacerbates platelet activation and myocardial infarction in patients with coronary artery disease

Xiaowen Wu, Guanxing Pan, Lin Chang, Yulong Zhang, Yangyang Liu, Wei Zhang, Yifan Guo, Ge Zhang, Haoxuan Zhong, Zhiyong Qi, Jianjun Zhang, Ruyi Xue, She Chen, Hu Hu, Jianzeng Dong, , Zhongren Ding

This study identifies TREM2 as a signaling hub linking ER stress, immune-inflammation, and platelet hyperactivity in CAD, showing that TREM2 downregulation exacerbates myocardial infarction and that TREM2-activating antibodies may offer therapeutic potential.

Journal of the American Heart Association · Jun 24, 2025Peer-reviewedPharmacology & Toxicology