Luciano E. Marasco

Nucleolar endonuclease MBLAC2 orchestrates co-transcriptional ribosomal RNA processing and global transcriptional output

This study identifies MBLAC2 as a nucleolar nuclease essential for co-transcriptional rRNA processing and global transcriptional output.

An SMN2 splicing-correcting antisense oligonucleotide promotes gene looping and transcription activation

The paper shows that an antisense oligonucleotide promotes gene looping and long-distance promoter activation through chromatin conformation changes.

Towards a combined therapy for spinal muscular atrophy based on opposing effects of an antisense oligonucleotide on chromatin and splicing

The paper shows that combining an ASO with HDAC inhibitors enhances SMN2 exon 7 inclusion in SMA mice, improving SMN expression and function.