Cell BiologybioRxivPreprint
Combined loss of ATG4B, ATG4C and ATG4D impairs systemic autophagy and triggers accelerated aging in mice
Gemma G. Martínez-García, María Fernanda Suárez, Mar Rodríguez-Santamaría…·Guillermo Mariño
This study shows that loss of ATG4B, ATG4C, and ATG4D in mice causes systemic autophagy defects, leading to accelerated aging and shortened lifespan.
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