Combined loss of ATG4B, ATG4C and ATG4D impairs systemic autophagy and triggers accelerated aging in mice
Gemma G. Martínez-García, María Fernanda Suárez, Mar Rodríguez-Santamaría, Víctor Celemín-Capaldi, David Roiz‐Valle, Clea Bárcena, Isaac Tamargo‐Gómez, Andrés Corrochano-Ruiz, Vsevolod Fedoseev, Oliva C. Fernández Cimadevilla, Pedro M. Quirós, Alejandro P. Ugalde, Pablo Mayoral, Aurora Astudillo, Christina Sveen, , Guillermo Mariño
This study shows that loss of ATG4B, ATG4C, and ATG4D in mice causes systemic autophagy defects, leading to accelerated aging and shortened lifespan.
bioRxiv · Jan 25, 2025 · PreprintCell Biology