The FusX TALE Base Editor (FusXTBE) for rapid mitochondrial DNA programming of human cells in vitro and zebrafish disease models in vivo
Ankit Sabharwal, Bibekananda Kar, Santiago Restrepo-Castillo, Shannon R. Holmberg, Neal D. Mathew, Benjamin Luke Kendall, Ryan P. Cotter, Zachary WareJoncas, Christoph Seiler, Eiko Nakamaru‐Ogiso, Karl J. Clark, Stephen Carl Ekker
The paper introduces FusXTBE, a TALE base editor for editing mtDNA in human cells and zebrafish, achieving high editing efficiency and precision.
The CRISPR Journal · Dec 1, 2021Peer-reviewedGenetics