Chimeric RNA:DNA Donorguide Improves HDR in vitro and in vivo
Brandon W. Simone, Han B. Lee, Camden L. Daby, Santiago Restrepo-Castillo, Gabriel Martínez‐Gálvez, Hirotaka Ata, William A.C. Gendron, Karl J. Clark, Stephen Carl Ekker
This paper introduces a Donorguide technology that improves HDR efficiency and precision by fusing an ssDNA template to tracrRNA, showing enhanced results in vitro and in vivo.
bioRxiv · May 28, 2021 · PreprintGenetics