Santiago Restrepo-Castillo

The paper generates a systematic in vivo atlas of loss-of-function alleles in zebrafish mitochondrial genes, revealing their impact on bioenergetics and hair cell function.

This paper designs sigma factor-based biomolecular classifiers and investigates how resource competition affects their performance and design principles.

This paper introduces DdCBEs with modified TALE proteins that remove the 5-T constraint, enabling efficient and specific mitochondrial base editing at previously inaccessible sites.

The paper introduces FusXTBE, a TALE base editor for editing mtDNA in human cells and zebrafish, achieving high editing efficiency and precision.

This paper introduces a Donorguide technology that improves HDR efficiency and precision by fusing an ssDNA template to tracrRNA, showing enhanced results in vitro and in vivo.