Author

Shannon R. Holmberg

Mayo ClinicORCID 0000-0003-2442-0029Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:zebrafish· 4 Assay:DNA methylation· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Research Focus:database / resource· 1 Organism:human· 1

Frequent Co-Authors

Ankit SabharwaliD· 4 shared Stephen Carl EkkeriD· 4 shared Bibekananda KariD· 3 shared Karl J. ClarkiD· 3 shared Mark D. WishmaniD· 2 shared Noriko IchinoiD· 2 shared Xiaolei XuiD· 2 shared Yonghe DingiD· 2 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersGenetics

Ankit SabharwalORCID

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4 papers

Recent·Most cited

GeneticsZebrafishPeer-reviewedSep 22, 2025

Non-Destructive Larval Genotyping of Danio rerio for Mitochondrial and Nuclear DNA Genetics

Kyler S. Mitra, Shannon R. Holmberg, Mireya Mota…·Stephen Carl Ekker

This paper develops a non-destructive method for genotyping zebrafish larvae for mitochondrial and nuclear DNA, validated through PCR and sequencing, and shows its utility for gene editing studies.

1 citation

zebrafishDNA methylation

𝕏 PostBluesky

GeneticseLifePeer-reviewedNov 21, 2022

A Genetic Model Therapy Proposes a Critical Role for Liver Dysfunction in Mitochondrial Biology and Disease

Ankit Sabharwal, Mark D. Wishman, Roberto Lopez Cervera…·Stephen Carl Ekker

This paper presents a zebrafish model of Leigh Syndrome, demonstrating liver dysfunction's critical role in mitochondrial disease through genetic rescue.

9 citations

zebrafishexperimental assay

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Molecular BiologyGenesPeer-reviewedJul 23, 2022

A primer genetic toolkit for exploring mitochondrial biology and disease using zebrafish

Ankit Sabharwal, Jarryd M. Campbell, Tanya L. Schwab…·Stephen Carl Ekker

The paper presents a collection of zebrafish genetic mutants for studying mitochondrial biology and disease.

15 citations

zebrafishexperimental assay

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GeneticsThe CRISPR JournalPeer-reviewedDec 1, 2021

The FusX TALE Base Editor (FusXTBE) for rapid mitochondrial DNA programming of human cells in vitro and zebrafish disease models in vivo

Ankit Sabharwal, Bibekananda Kar, Santiago Restrepo-Castillo…·Stephen Carl Ekker

The paper introduces FusXTBE, a TALE base editor for editing mtDNA in human cells and zebrafish, achieving high editing efficiency and precision.

38 citations

humanzebrafish

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